MaXLinker: Proteome-wide Cross-link Identifications with High Specificity and Sensitivity
نویسندگان
چکیده
منابع مشابه
Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification
We describe optimized fragmentation schemes and data analysis strategies substantially enhancing the depth and accuracy in identifying protein cross-links using non-restricted whole proteome databases. These include a novel hybrid data acquisition strategy to sequence cross-links at both MS2 and MS3 level and a new algorithmic design XlinkX v2.0 for data analysis. As proof-of-concept we investi...
متن کاملComparison sensitivity and specificity temporal artery temperature measurement with axillary and nasopharyngeal methods in adult
Aims: temporal artery thermometers (TAT) of new tools for measuring body temperature, few studies have been conducted to evaluate the accuracy and reliability of thermometers and is still uncertain accuracy and reliability this thermometers.This study to evaluate the accuracy of the two methods of measuring body temperature by the thermometer axillary and temporal artery compared with nas...
متن کاملSensitivity And Specificity Of Procalcitonin In Diagnosis Of Neonatal Sepsis
Background and Objective: According to the fact that neonatal infection is a challenging diagnosis field, several studies have tried to test sensitivity and specificity of diagnostic tests. This study was conducted to evaluate the sensitivity and specificity of procalcitonin (PCT) as a single early marker of neonatal sepsis. Materials and Methods: In this study, 150 neonates admitted to NIC...
متن کاملStress, specificity and the NEDD8 proteome
Mechanisms controlling the p53 regulatory network remain the focus of numerous investigations in hopes of identifying more robust cancer therapies. Both Mdm2 and MdmX are found overexpressed in tumors with wild-type p53 and represent a key molecular device modulating p53 function. Thus, examining the interplay between these three proteins becomes highly relevant in the search for new pharmacolo...
متن کاملHigh-sensitivity detection using isotachophoresis with variable cross-section geometry.
We present a theoretical and experimental study on increasing the sensitivity of ITP assays by varying channel cross-section. We present a simple, unsteady, diffusion-free model for plateau mode ITP in channels with axially varying cross-section. Our model takes into account detailed chemical equilibrium calculations and handles arbitrary variations in channel cross-section. We have validated o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2020
ISSN: 1535-9476
DOI: 10.1074/mcp.tir119.001847